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10.1038/s41586-019-1707-0 31 DreishpoonM

The reaction mixtures were incubated at 30 C for 60 min, and the reactions were then stopped by boiling for 10 min

Black Box Warnings for Topical Cocaine: NOT FOR INJECTION OR OPTHALMIC USE Pharmacokinetics: A topical local anesthetic (its only FDA approved use) As a drug of abuse the HCl can be sniffed, taken orally or injected IV